Acetylcholinestersae [41], Beta-secretase [42] and amyloid-β precursor protein (ABPP) [43] are key enzymes mainly involved in pathology of AD and production of amyloid-β deposits, while SFRP4 as modulator of Wnt/β-catenin signaling pathway also implicated in AD pathology [44]. The gene discussed is APP; the disease is Alzheimer disease.