Similarly, research by Brandon A. Mahal et al. found that among patients with cT1-4N0M0 PCa and GS ≥ 8 who underwent RT, ADT conferred an overall survival benefit for those with PSA > 2.5 ng/mL, but not for those with PSA ≤ 2.5 ng/mL, further indicating resistance to ADT in this subgroup[6]. Here, KLK3 is linked to posterior cortical atrophy.