GSEA on negatively co-expressed genes showed terms mostly related to DNA structure and transcription such as chromatin modifying enzymes, transcriptional regulation by TP53, histone H3 methyltransferase activity, histone acetyltransferase activity, chromatin organization, genes with mutations in cancer-associated histone deacetylation and methylation (Fig 8B). This evidence concerns the gene TP53 and cancer.