Our findings necessitate the exploration of the role of ANGPTL4 in different cancers such as glioblastoma, lower grade glioma, renal cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, ovarian carcinoma, and rectal adenocarcinoma, as targeting ANGTPL4 could be of therapeutic benefit. The gene discussed is ANGPTL4; the disease is cancer.