Our findings necessitate the exploration of the role of ANGPTL4 in different cancers such as glioblastoma, lower grade glioma, renal cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, ovarian carcinoma, and rectal adenocarcinoma, as targeting ANGTPL4 could be of therapeutic benefit. This evidence concerns the gene ANGPTL4 and hereditary clear cell renal cell carcinoma.