Conversely, the positively co-expressed genes revealed terms like TGF-beta regulation of extracellular matrix, positive regulation of cell motility, positive regulation of intracellular signal transduction, positive regulation of cell migration, extracellular matrix organization, neoplasm metastasis, HIF-1 transcriptional activity in hypoxia, and MAPK signaling pathway (Fig 8C). This evidence concerns the gene HIF1A and neoplasm.