TGFB1 and breast cancer: In a study investigating the effect of phenolics secoiridoids such as HTyr, Ole aglycone in EO on TGFB1-induced fibrogenic and oncogenic EMT in Madin–Darby canine kidney (MDCK) cells and human breast cancer (MCF-7) cells, it was determined that the expression of the epithelial marker E-cadherin decreased and the expression of the mesenchymal marker Vimentin increased with TGFß1 induction in MDCK cells, and then after the cells were treated with EO, the expression of E-cadherin increased significantly and the expression of Vimentin was significantly inhibited.