According to polynominal regression analaysis results, meaningful relations were detected between TGFβ1 Concentration levels and all of LW, CIS, BMS, MDA, TGFβ1 Expressions, Casp-3 + cells and HPS for lung (p < 0.001) (Table 6, Fig 4). This evidence concerns the gene CASP3 and in situ carcinoma.