TGFB1 and breast carcinoma: It has been reported that phenolics secoiridoids such as HTyr, Ole aglycone in EO, act as anti-aging phytochemicals by inhibiting TGFB1-induced fibrogenic and oncogenic EMT in Madin–Darby canine kidney (MDCK) cells and human breast cancer (MCF-7) cells [33].