The current work adds to this literature by defining the role of local (but not systemic) hemolysis in aspergillosis, via a positive feedback loop in which lung hemorrhage and release of extracellular heme both promotes the growth of the pathogen and mediates further lung injury, thus causing further hemorrhage and local hemolysis — and defining the key role of hemopexin in protecting against this deleterious cycle. This evidence concerns the gene HPX and hemorrhage.