Nonmigratory dermal fibroblasts from SSc demonstrated an activated fibrotic profile similar to SSc migratory fibroblasts in terms of levels of CCN2 and COL1; however, they showed significantly different expression of αSMA compared with SSc migratory fibroblasts (P < 0.05), confirming a similar but not identical profibrotic phenotype (Figure 1, B–D). Here, ACTA1 is linked to systemic sclerosis.