Live-cell microscopy visualized cellular fates of multipolar mitotic events, as shown in Figure 4A. The majority of the displayed H1299 and A549 lung cancer cells exhibited a marked apoptotic response after either CYC065 treatment at the 0.2 μM or 0.5 μM drug concentrations, as evidenced by the prominence of treated cancer cells that exhibited annexin V staining, as displayed in Figure 4B and Supplemental Figure 3, A and B. The gene discussed is ANXA5; the disease is cancer.