This confirmed that failed cytokinesis or fusion of progeny cells after CDK2 inhibition augmented multipolar division, leading to the formation of multinucleated progeny in Figure 5B. These findings were confirmed and extended by use of FIB-SEM analysis of the CYC065-treated human H1299 lung cancer cell line, as seen in Supplemental Figure 3C. The gene discussed is CDK2; the disease is lung cancer.