To interrogate the cellular environment of CLAD-BOS, we performed scRNA-Seq on enriched immune (CD45+) and nonimmune (CD45–) fractions from distal lung explants from patients undergoing second lung transplantation with CLAD-BOS (n = 4) compared with normal age- and sex-matched controls (NC) (n = 3) (Figure 1A and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.176596DS1). Here, PTPRC is linked to Buschke-Ollendorff syndrome.