CKD (or atrophy-fibrosis) in transplant biopsies was associated with a separate constellation of changes: increased expression of transcripts representing plasma cells, e.g., immunoglobulin transcripts (IGTs) (5); mast cell transcripts (MCATs), e.g., CPA3 and FCER1A (6); and others such as CXCL6, a chemokine increased in progressing CKD but not in AKI (6). The gene discussed is CPA3; the disease is chronic kidney disease.