Patients with FA-B with disruptive FANCB mutations showed earlier-than-average onset of BMF and more severe congenital anomalies, including frequently the association of vertebral (V), anal atresia (A), cardiac (C), tracheo-esophageal fistula (T), esophageal/duodenal atresia (E), renal (R), and limb (L) (VACTERL) abnormalities, compared with a large series of individuals with FA (44). This evidence concerns the gene FANCB and Friedreich ataxia.