In particular, subjects in Mayo stage IIIb (NTproBNP > 8500 ng/L or BNP > 700 ng/L, troponin T > 0.035 μg/L or troponin I > 0.1 μg/L or high-sensitivity troponin T > 54 ng/L), who accounts for around 20% of AL population, are characterised by median survival of 4–6 months [89]. Here, NPPB is linked to axial length measurement.