In short, PRAC2 is specifically expressed in the prostate, bladder, vagina, testis and colon and may be connected to prostate cancer and cellular senescence [66, 67]; FOCAD may have an important function in maintaining liver health, with mutations increasing the risk for early-onset liver cirrhosis [68]; DNAJB13 is primarily expressed in the testis and fallopian tube and has been implied to affect male infertility as well as increasing stress resistance potentially through the antioxidant pathway [69, 70]. Here, PRAC2 is linked to cirrhosis of liver.