Gene set enrichment analyses of KEGG pathway gene orthologs in MSigDB revealed a significant downregulation of genes involved in cytokine receptor signaling along with immunodeficiency and B-cell receptor (BCR) signaling, which included myriad B/T/plasma cell maturation-specific surface receptors and lineage specification genes (Table S2; Fig. 1A-C; S1A). This evidence concerns the gene BCR and immunodeficiency disease.