CASP1 and Cognitive impairment: The relative expression levels of NLRP3 (p < 0.05) (Figure 9A), ASC (p < 0.05) (Figure 9B), and Caspase-1 (p< 0.05) (Figure 9C) in the jejunum of the model group were significantly increased, indicating that intestinal inflammation was increased in mice with cognitive impairment induced by sleep deprivation.