The relative expression levels of NLRP3 (p < 0.05) (Figure 9A), ASC (p < 0.05) (Figure 9B), and Caspase-1 (p< 0.05) (Figure 9C) in the jejunum of the model group were significantly increased, indicating that intestinal inflammation was increased in mice with cognitive impairment induced by sleep deprivation. The gene discussed is NLRP3; the disease is Cognitive impairment.