Asprosin weakens insulin signaling in skeletal muscle and induces insulin resistance via inflammatory mechanisms.[28, 29] Moreover, it amplifies inflammation in both endothelial cells and macrophages.[30, 31] However, one study has reported that asprosin mitigates the progression of atherosclerosis.[32] Given these contradictory findings and the absence of correlational studies, it is imperative to conduct in‐depth research on the precise role of asprosin in metabolic processes. This evidence concerns the gene INS and atherosclerosis.