Hepatocyte‐specific overexpression of asprosin aggravated HFCDAA diet‐induced hepatic lipid accumulation and steatosis in mice, as shown by liver Oil red O and HE staining, whereas simultaneous knockdown of hepatic OR4M1 failed to reverse the effects of asprosin and the livers still contained a large number of lipid droplets and fat vacuoles (Figure S5k,l, Supporting Information). The gene discussed is FBN1; the disease is steatosis.