IL6 and colorectal carcinoma: In CRC, it has been established that inflammatory factors produced in the TME are associated with low microsatellite instability (MSI‐L) and EMAST, preferably in ulcerated tumors with oxidative stress, interleukin 6 (IL‐6) and prostaglandin E2 (PGE2) production, leading to the displacement of MSH3 from the nucleus to the cytoplasm and increasing the appearance of EMAST.