CD4 and neoplasm: On the other hand, this novel X‐PDT strategy could exert a potent immunomodulatory effect far superior to conventional SBRT by pyroptosis‐induced tumor cells’ ICD process, including enhancing the immunogenicity of tumor cells, promoting functional CD4+ and CD8+ T‐cell infiltration, stimulating DC maturation, and provoking macrophages M1 polarization, ultimately transforming the immunosuppressive microenvironment into an immune‐responsive tumor microenvironment and increasing sensitivity to immunotherapy.