The results showed that N@VP, 2 Gy, and N@VP + 2 Gy treatment all had significantly promoted CD3+CD8+ T cell infiltration into tumor tissues, while the amount of CD3+CD8+ T cells in both spleen and lymph nodes was only significantly increased in the N@VP + 2 Gy group, indicating a more potent immune response triggered by N@VP‐enhanced radiotherapy. Here, CD8A is linked to neoplasm.