On the other hand, this novel X‐PDT strategy could exert a potent immunomodulatory effect far superior to conventional SBRT by pyroptosis‐induced tumor cells’ ICD process, including enhancing the immunogenicity of tumor cells, promoting functional CD4+ and CD8+ T‐cell infiltration, stimulating DC maturation, and provoking macrophages M1 polarization, ultimately transforming the immunosuppressive microenvironment into an immune‐responsive tumor microenvironment and increasing sensitivity to immunotherapy. Here, CD8A is linked to neoplasm.