More importantly, for highly radio‐insensitive tumors, regulating DC activation status and Treg function is predominant to successfully generate effector T‐cell‐mediated antitumor immune response,[32] while this therapy is also able to stimulate superior antitumor immune response than conventional SBRT, including M1 macrophage polarization, DCs’ maturation, Treg infiltration inhibition, and T‐cell activation, through inducing Caspase‐1‐GSDMD‐pyroptosis pathway in tumor cells. Here, GSDMD is linked to neoplasm.