CD8A and neoplasm: However, not all patients benefit from immunotherapy due to lack of sufficient T‐cell infiltration, impaired activation of immune cells, and immune‐related adverse events,[45] while in this study, N@VP combined with IR treatment successfully promoted more mature immune cells’ infiltration, particularly antigen‐specific memory CD8+ T cells, by inducing tumor cell pyroptosis, and also enhanced sensitivity to checkpoint‐targeted immunotherapies through upregulating PD‐1 expression, thus realizing dual sensitization of both radiotherapy and immunotherapy in the combined treatment of tumors.