DENND4A and cancer: Among these upregulated genes, Dennd4a, Nfil3, Hspa1b, Chac1, Ddit4, Mex3b, Lysmd3, and Zbtb10 are mainly involved in oxidative stress and inflammation response, whereas Plcxd2, Dusp1, Cep85l, and Dusp8 are generally considered as tumor‐suppressor genes by inhibiting proliferation of cancer cells.