Mature DC upregulated expression of MHC‐II and co‐stimulatory molecules (CD80/CD86), promoting naïve CD4+ T cell differentiation to Th1 CD4+ cells, meanwhile, more effectively activating and presenting tumor antigens to T cells.[38] A polarization of M2 macrophages into M1 macrophages after N@VP‐enhanced radiotherapy is considered to be an effective antitumor immunological response inducer because M1 macrophage is a favorable macrophage subtype associated with remarkable tumor‐killing capacity via engulfing tumor cells and secreting tumor cell toxic cytokines directly. This evidence concerns the gene CD4 and neoplasm.