Similarly, compared to N@VP + 2 Gy group, minimal inhibitory effect on tumor growth after both BNP or BNP + 2 Gy treatment excluded antitumor effect from BNP or a synergistic effect between BNP and irradiation, further reinforcing the role of VP combined with gelatinase‐responsive nanoparticles as an effective radiosensitizer for cancer therapy (Figure S18a–c, Supporting Information). This evidence concerns the gene NPPB and cancer.