HMGB1 and neoplasm: Upon cleavage by activated caspase1, GSDMD forms its N‐terminal domain (GSDMD‐N), which binds to cellular membrane phospholipids and creates pores on the membrane, followed by rupture of tumor cell membrane and then fast release of multiple pro‐inflammatory signals (IL‐1β and IL‐18) and cellular alarmins (ATP, HMGB1, chemokines, and other cytokines).[33] These inflammatory signals amplify inflammation in tumor tissues and mobilize immune cells in response to threats.