The ectopic CXCL13 expression was involved in the pathogenesis of various immune‐mediated inflammatory diseases as it regulated the migration of B lymphocytes, T lymphocytes, and other immune cells in inflammatory sites as well as influenced the expression of inflammatory factors.[23] Based on the above research and our study results, it is concluded that excessive CXCL13 is one of the main reasons for BSCB damage and inflammatory cell infiltration during the development of EAE and MS. Here, CXCL13 is linked to myeloid sarcoma.