Similar to our results, previous studies reported that cardiac‐specific Trim44 knockout attenuates isoproterenol‐induced cardiac remodeling by inhibiting the AKT/mTOR pathway.[39] Collectively, these findings illustrate the important role of Trim44 in Kdm4a‐mediated premature senescence and cardiac interstitial fibrosis. Here, KDM4A is linked to Interstitial cardiac fibrosis.