Kdm4a, which acts as an eraser of H3K9me3,[29, 30] was reported to significantly exacerbate bleomycin‐induced lung and liver fibrosis by promoting the transition of myofibroblasts.[31, 32] A recent study also revealed that Kdm4a could promote senescence in pancreatic cancer and nucleus pulposus cells.[33, 34] Moreover, Kdm4a was found to orchestrate epigenomic remodeling in senescent cells, potentiating the SASP.[29] The above results indicate the potent role of Kdm4a in regulating cellular senescence in cardiac fibrosis. The gene discussed is KDM4A; the disease is pancreatic neoplasm.