Previous studies have reported that antifibrotic factors, such as plasminogen activators and macrophage‐derived VSIG4,[44, 45] not only reduce excessive cardiac interstitial fibrosis in the advanced stage (7 days post‐MI), but also unfortunately increase the incidence of cardiac rupture in the first week after MI, which could result in undesirable consequences. Here, VSIG4 is linked to Interstitial cardiac fibrosis.