In addition, Kdm4a was silenced by an adeno‐associated virus carrying the fibroblast‐specific Postn promoter, which is widely used to deliver target genes in fibroblasts, but the use of fibroblast‐specific knockout and overexpression transgenic mice may be helpful in determining the role of Kdm4a in cardiac interstitial fibrosis. This evidence concerns the gene POSTN and Interstitial cardiac fibrosis.