IL6 and periodontitis: Prior research has indicated a connection between diet and inflammatory biomarkers, with calorie restriction inhibiting the inflammatory response and lowering inflammatory mediators in gingival sulcus fluid, including interleukin-6, tumor necrosis factor-α, and plasma C-reactive protein.30 According to Li et al,17 a pro-inflammatory diet is linked to a higher chance of developing periodontitis (OR: 1.53, 95% CI: 1.33-1.77, p < 0.05).