We evaluated the correlations between HLA‐DQB1*05:02 genotypes and clinicopathological factors, such as tumor stage, age (< 40 vs. ≥ 40 years), lymph node metastasis, extra–nodal extension (ENE), and tumor differentiation (Figure 2B). This evidence concerns the gene HLA-DQB1 and metastatic malignant neoplasm in the lymph nodes.