reported that circRNA‐SORE, present in sorafenib‐resistant HCC cells, binds to the oncogenic protein YBX1, preventing its degradation by the E3 ubiquitin ligase PRP19, enhancing sorafenib resistance in HCC.[8] These studies suggest that circRNAs alter total amount of RBP by stabilizing proteins in the context of drug resistance in HCC. Here, PRPF19 is linked to hepatocellular carcinoma.