PRPF19 and hepatocellular carcinoma: Consequently, the degradation of YBX1 mediated by PRP19 was inhibited, resulting in enhanced sorafenib resistance in HCC.[8] In another study, researchers found that m6A modification promoted circRNA‐SORE expression, which acted as a microRNA (miRNA) sponge, separating miR‐103a‐2‐5p and miR‐660‐3p.