As autophagy may play a crucial role in the development of targeted drug resistance in HCC samples,[10] we intersected the parent genes of these differentially expressed circRNAs with genes in the Kyoto Encyclopedia of Genes and Genomes database (hsa04140 dataset), resulting in four intersecting genes: AMBRA1, mTOR, ATG7, and PIK3C3 (Figure 1B; File 2, Supporting Information). The gene discussed is PIK3C3; the disease is hepatocellular carcinoma.