Consistent with its ability to inhibit the BCL10-MALT1 interaction, this compound blocks both MALT1 protease and scaffolding activities and also potently drives a decrease in BCL10 and MALT1 protein levels within ABC-DLBCL cells, likely due to disruption of the self-stabilizing interaction of the BCL10 and MALT1 proteins (36, 37). Here, MALT1 is linked to diffuse large B-cell lymphoma.