IL6 and diffuse large B-cell lymphoma: To evaluate the effect of M1i-124 and M1i-124d1 on NF-κB–dependent cytokine expression and secretion in ABC-DLBCL cells, we treated two ABC-DLBCL cell lines, TMD8 and OCI-Ly3, with 1 μM of M1i-124 or M1i-124d1 for 24 hours and found that this was sufficient to significantly decrease IL6 and IL10 mRNA levels (Figure 4C and Supplemental Figure 5C).