Together, these results demonstrate that M1i-124 inhibits both cell proliferation and viability of MALT1-dependent ABC-DLBCL cells, but not MALT1-independent GCB-DLBCL cells, and that the effect on ABC-DLBCL cells is at least partially due to induction of apoptosis. The gene discussed is MALT1; the disease is diffuse large B-cell lymphoma.