To evaluate the effect of M1i-124 and M1i-124d1 on NF-κB–dependent cytokine expression and secretion in ABC-DLBCL cells, we treated two ABC-DLBCL cell lines, TMD8 and OCI-Ly3, with 1 μM of M1i-124 or M1i-124d1 for 24 hours and found that this was sufficient to significantly decrease IL6 and IL10 mRNA levels (Figure 4C and Supplemental Figure 5C). Here, NFKB1 is linked to aneurysmal bone cyst.