Indeed, symptoms of hydralazine-induced vasculitis comprise a wide variety of clinical signs depending on where the IgM hydrazone-MPO complexes are deposited, including skin rashes with hives, bruising, and the presence of edema, joint inflammation, numbness or tingling due to nerve damage, fever, and, in severe cases, the vasculitis can lead to severe organ damage in the kidneys, heart, and lungs. The gene discussed is MPO; the disease is vasculitis.