INS and type 2 diabetes mellitus: RPS6KB1S452, a protein involved in mTOR signaling and whose phosphorylation is increased by insulin stimulation, also showed increased phosphorylation in T2D cells, as did phosphorylation of FOXK1S468, a transcription factor involved in insulin action that can physically interact with IRs (50) and play a role in the regulation of the gluconeogenic genes PCK1 and G6Pc in the liver (51).