RPS6KB1 and type 2 diabetes mellitus: In the present study, the signal transduction proteins EIF4B, RPS6, RPS6KB1, and TSC2 also showed impaired phosphorylation in T2D, as did ERBIN, MARK3, and several proteins involved in Rho GTPase signaling, including the Rho GAPs ARHGAP32, Rho GEFs (ARHGEF7, ARHGEF11), and the Rho effector FARP1 (Supplemental Figure 3, B and C, and Supplemental Table 3).