INS and type 2 diabetes mellitus: Probing the specific amino acid sequences surrounding the phosphoserines and phosphothreonines in our phosphoproteomics data against this database, we sought to identify the kinases involved in insulin signaling in iHeps and those that are altered in activity in T2D by ranking the top S/T kinases predicted to target that phosphorylation site and creating a percentile score, as previously described (61).