INS and type 2 diabetes mellitus: Interestingly, 3 proteins involved in RNA splicing lost insulin regulation of sites of tyrosine phosphorylation normally downregulated following insulin stimulation, including PCBP2Y46, PRPF4BY140, and SF3B2Y379, suggesting loss of action of a nuclear tyrosine kinase or gain of action of a nuclear tyrosine phosphatase in T2D cells.