INS and type 2 diabetes mellitus: Considering only sex-common sites that exhibited an increase or decrease in phosphorylation upon insulin stimulation in control or T2D iHeps with a P value of less than 0.05 and a ±1.5-fold change, 1,007 phosphosites exhibited increases in phosphorylation and 703 sites exhibited decreases in phosphorylation upon insulin stimulation in either the control iHeps, T2D iHeps, or both (Supplemental Figure 2B and Supplemental Table 2).