The kinome analysis also predicted reduced activity of several other kinases, including PKCθ, YANK3 (STK32c), AMPKA2, BRSK2, MAPKAPK2, CHK2, PHKG2, TTBK2, and WNK3, as contributors to the impaired insulin-stimulated phosphorylations observed in T2D iHeps (Figure 6A, highlighted with black arrows). The gene discussed is PRKAA2; the disease is type 2 diabetes mellitus.