Thus, ROCK1 protein levels and activity are increased in the liver of mice on a high-fat diet (HFD) (63), BCAA metabolism has been linked to insulin resistance and T2D (20), and the STE20-type kinases MST3 and MST4 have been linked to the progression of hepatocellular carcinoma (64). This evidence concerns the gene STK26 and type 2 diabetes mellitus.