We identified in these unrelated infections, and especially in bacterial diseases (except Lyme borreliosis for SLAMF8), significant differences between healthy donors (HDs) and infected individuals in the RNA expression of SLAMF7 and SLAMF8 (Figure 1A and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI182467DS1). Here, SLAMF7 is linked to Lyme disease.