This coregulation is consistent with the simultaneous variation of SLAMF7 and SLAMF8 mRNA expression in our human blood transcriptomic analyses from a wide range of infectious disease patients, but differs from the sole upregulation of SLAMF7, and not SLAMF8, in PBMCs and monocytes/macrophages of sepsis patients or inflamed synovial tissue (27, 50). This evidence concerns the gene SLAMF7 and infectious disease.