SLAMF8 and infection: We identify SLAMF7 and SLAMF8 as receptors that positively regulate human pDC function during infection with two types of intracellular bacteria known to drive either a strong acute inflammatory response (and high clearance except for 2%–5% of patients) (Salmonella enterica Typhimurium) (22) or a mild acute phase (undulant fever), often unnoticed, followed by a chronic multiorgan inflammatory stage of infection (Brucella abortus) (23).