Since SLAMF7 and SLAMF8 genes were differentially expressed in the blood transcriptome of patients suffering from infection with Salmonella, a paradigm of bacteria that drive acute inflammation (Figure 1A), we analyzed in depth a first cohort of salmonellosis patients comprising enteric fever patients with positive cultures for both Salmonella enterica Typhi and Salmonella enterica Paratyphi (33). The gene discussed is SLAMF7; the disease is salmonellosis.