Cross-linking of SLAMF7 or SLAMF8 in human primary pDCs significantly increased the expression of maturation markers (HLA-DR, CD80, CD86) and of the coinhibitory molecule PD-L1 at 24 hours after infection with S. Typhimurium when compared with the levels observed in the isotype control antibody condition (Figure 6A). The gene discussed is CD274; the disease is infection.