The association of a type I IFN signature with SLAMF7 and SLAMF8 upregulation in brucellosis and salmonellosis patients together with their high expression in pDCs and the known role of these cells in type I IFN production led us to explore the expression of these 2 surface receptors in purified human pDCs at resting state and after exposure to various stimuli comprising TLR ligands and bacterial components (Figure 3C and Supplemental Figure 2A). This evidence concerns the gene SLAMF8 and brucellosis.