MSH2 and colorectal carcinoma: The cumulative incidence of a first CRC by the age of 75 years for path_MLH1 and path_MSH2 carriers with no prior CRC was 49.9% (95% c.i. 45.0% to 55.1%) and 45.8% (95% c.i. 40.6% to 51.3%) respectively (Table 2 and Fig. 1).