LEP and obesity due to melanocortin 4 receptor deficiency: Those children who have poor quality and quantity of sleep raise the likelihood of metabolic and endocrine deviations [86], including, e.g., ﻿"decreased insulin sensitivity, decreased glucose tolerance, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite" [87] that trigger obesity [88,89].