We subsequently combined the statistically significant features from Table 1 for joint prediction, and the results revealed that combining the IGFBP-2 score with the APACHE II score, the SOFA score, and the use of vasopressors improved the prediction of SA-AKI, with an AUC of 0.9604, a sensitivity of 93.18%, and a specificity of 82.86% (Table 2). The gene discussed is IGFBP2; the disease is acute kidney injury.