Abbreviations: AKI, Acute Kidney Injury; IGFBP-2, Insulin-Like Growth Factor-Binding Protein-2; Sequential Organ Failure Assessment (SOFA) Score, ranging from 0 to 24, with higher scores indicating more severe organ dysfunction; APACHE II, Acute Physiology and Chronic Health Evaluation II; p < 0.05, statistically significant. The gene discussed is IGFBP2; the disease is acute kidney injury.