Ethylglyoxal bisthiosemicarbazon (ETS) specifically killed HCC cells by inhibiting the phosphorylation of the Tyr285 of LAPTM4B-35, which is involved in the activation of the PI3K/AKT signaling pathway induced by LAPTM4B-35 overexpression (111). This evidence concerns the gene LAPTM4B and hepatocellular carcinoma.