Increased expression of LAPTM4B-35 and LAPTM4B-24 affects the invasion, metastasis and chemotherapy resistance in a variety of tumor cells, e.g., gastric, breast, colon, ovarian, liver, pancreatic, cervical, prostate, lung, endometrial, and gallbladder cancers (28–43). The gene discussed is LAPTM4B; the disease is gallbladder cancer.