The study revealed that LAPTM4B is not only involved in chemoresistance by affecting drug efflux, but also promotes chemoresistance of cancer cells by activating the phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)/AKT signaling pathway and regulating intracellular signaling networks (77–81). The gene discussed is LAPTM4B; the disease is cancer.