Meanwhile, LAPTM4B knockdown inhibited tumor cell migration and invasion, possibly by downregulation of related proteins such as matrix metalloprotein 2 (MMP-2), matrix metalloprotein 9 (MMP-9), cell cycle-dependent protein kinase 12 (CDK12) and Hypoxia-inducible factor 1-alpha (HIF-1α) (Figure 2A) (45). This evidence concerns the gene HIF1A and neoplasm.