Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in the invasion, metastasis, and causing drug resistance to LSC, and FGFR1 can be an independent prognostic factor for LSC, mainly overexpression of FGFR1 is linked to lymph node metastasis and poor survival outcomes. This evidence concerns the gene FGFR1 and metastatic malignant neoplasm in the lymph nodes.