Regarding molecular proteins as prognostic and diagnostic markers in the LSC, we found TP53, CD1, Bcl2L12, P21, p27, EGFR, E-cadherin, β-catenin, FAK, NOTCH, FGFR1, PTEN, DJ-1, and TrkB are the possible markers to inhibit the tumor stages as they are involved in the cell cycle progression and cell cycle arrest in the LSC. Here, BCL2L12 is linked to neoplasm.