PTEN and neoplasm: Regarding molecular proteins as prognostic and diagnostic markers in the LSC, we found TP53, CD1, Bcl2L12, P21, p27, EGFR, E-cadherin, β-catenin, FAK, NOTCH, FGFR1, PTEN, DJ-1, and TrkB are the possible markers to inhibit the tumor stages as they are involved in the cell cycle progression and cell cycle arrest in the LSC.