MAPK10 and obesity due to melanocortin 4 receptor deficiency: The study demonstrated the association of obesity and dyslipidemia with dysregulation of DNA hydroxy methylation of genes related to apoptosis and senescence, as studied in animal and human mesenchymal stem cells. The epigenetic 5 hmc marker levels of CDKN2C and TERT protein expression were raised compared to 5 hmc levels of the MAPK10 gene in obese mesenchymal stem cells.