ADCY3 and coronary artery disorder: Furthermore, another study identified a significant association between the GG genotype at the rs6751537 locus within the ADCY3 gene and CAD, revealing that individuals presenting abnormal blood lipid profiles or high genetic risk at the rs6751527 locus had a CAD prevalence rate 7.43 times higher than those with normal blood lipids or low genetic risk (Ye et al., 2022).