In pancreatic ductal adenocarcinoma, BRCA1 and BRCA2 proteins are involved in DNA damage recognition and repair by homologous recombination, The mutation results in the inability to repair broken double-stranded DNA and increased sensitivity to cytotoxic drugs such as platinum, and the use of platinum-based chemotherapy protocols improves OS and DFS in patients with BRCA1/BRCA2 mutations (23). The gene discussed is BRCA1; the disease is pancreatic ductal adenocarcinoma.