A recent analysis underscored thesignificance of Notch receptors in the tumorigenic activity of Notch signaling pathways across multiple cancer types, including lungadenocarcinoma, cervical cancer, haematological malignancies, breast cancer and ovarian cancer [14].Ligand binding and activation are critically dependent on the extracellular portion, which is characterized by multiple repeating units,similar to epidermal growth factor (EGF) [15]. Here, EGF is linked to cancer.