MicroRNAs (miR-21, miR-31) and cytokines (IL-8)are useful biomarkers in oral and maxillofacial pathology for early identification of oral squamous cell carcinoma (OSCC), which boostsprognosis through facilitating prompt diagnosis, especially for high-risk groups such as smokers or those who were exposed to the humanpapillomavirus (HPV) [21]. Here, CXCL8 is linked to oral cavity squamous cell carcinoma.