Various treatment modalities presently used are lifestyle-behavioural moderation and pharmaceuticalinterventions, including oral anti-hyperglycaemic agents, including non-sulfonyl urea secretagogues, biguanide, DPP-IV inhibitors, alphaglycosidase inhibitors, thiazolidinedione's, GLP-1 analogues, SGLT2 inhibitors, 11β-HSD-1 inhibitors and insulin [4].They aimed at preventing and controlling hyperglycaemia, ensuring the adequate glucose delivery to the various tissues and attempting to decreasethe harm caused by hyperglycaemia [3]. This evidence concerns the gene INS and Hyperglycemia.