In the ovalbumin-expressing B16-F10 (OVA-B16-F10) melanoma model, PLGA-NPs containing (si-SIRPα/cGAMP) reversed the immunosuppressive phenotype of APCs, promoting the activation of OVA-specific CD8+ T cells and generating comprehensive anti-tumor immune responses [199]. Here, CD8A is linked to neoplasm.