Diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2) represents a distinct entity of mature aggressive B-cell lymphoma, which is either de novo DLBCL or transformed from indolent lymphoma (1, 2). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.