The Kaplan-Meier plotter database assessed the prognostic significance of KCNE4, SOX7, SEZ6L2, and LARS2. Our findings revealed a significant negative correlation between SEZ6L2 and SOX7 with the prognosis of COAD, while LARS2 demonstrated a positive correlation. The gene discussed is SEZ6L2; the disease is colon adenocarcinoma.