VPS37D and colorectal cancer: Although studies on the relationship between VPS37D and cancer are relatively limited, existing studies have shown that VPS37D frameshift mutations (incidence 7.1%) were detected in microsatellite unstable (MSI)-type gastric cancer and colorectal cancer, indicating that mutations disrupt the membrane-binding capacity of the ESCRT-I complex and affect endosomal protein sorting, confirming for the first time that VPS37D is a potential driver gene for digestive tract tumors (48).