TKT and cancer: To further investigate the involvement of TKT in cancer biology, we assessed its relationship with 10 cancer-related pathways—TSC/mTOR, RTK, PI3K/AKT, RAS/MAPK, hormone ER, hormone AR, DNA damage response, cell cycle, epithelial–mesenchymal transition (EMT), and apoptosis—using protein expression data from the RPPA in the TCPA database (21).