STAT3 and neoplasm: In these factors, like Interferon Regulatory Factor 1 (IRF1) and Nuclear factor, erythroid 2 like 2 (NFE2L2) have been reported to function in the anti-tumor capacity (67, 68), while HIF-1 alpha (HIF1A) and Signal transducer and activator of transcription 3 (STAT3) to support tumor growth and immune evasion (69, 70).