SPP1 and neoplasm: We observed that SPP1+ TAMs (tumor core: 41.95%, peri-tumor: 23.43%), CXCL9+ TAMs (8.88%, 22.65%), TREM2+ TAMs (13.53%, 13.42%) and SLC40A1+ TAMs (11.02%, 18.93%) mainly existed in tumor region, while the other subtypes, like CLEC10A+ TAMs (normal: 41.82%) were notably present in normal tissues, which may reflect the functional heterogeneity of the subsets in the TME.