AKT1 and neoplasm: Moreover, PI3K/AKT/mTOR signaling pathway, an important role in regulating angiogenesis both in normal tissues and in cancers, was reported to be involved in T-cadherin related tumorigenesis of human gastric cancer and cervical cancer, since sustained activation of AKT1 in endothelial cells has been shown to induce the formation of abnormal blood vessels, which was similar to the aberrations of tumor vessels (82–84).