In plasma, Adiponectin exists in a variety of complexes, including trimers (LMW, low molecular weight), hexamers (MMW) and high molecular weight multimers (HMW), exerting protective functions in insulin−sensitizing, anti−inflammation, anti−proliferation, anti−atherosclerotic action and tumor suppression of various tissues (87). The gene discussed is ADIPOQ; the disease is neoplasm.