Considering the environment of KRAS-promoted lung adenocarcinoma, CUL4B exerts its tumor-suppressing capabilities via intricate epigenetic processes that encompass coordinated interplay with HDACs, ultimately inhibiting the transcription of C-X-C motif chemokine ligand 2 (CXCL2) (81). The gene discussed is CUL4B; the disease is neoplasm.