This focus on HDACs is justified as the current research on KRAS-promoted lung adenocarcinoma primarily highlights the role of HDACs in the epigenetic regulation of CXCL2, while the involvement of PRC2 in this context is less documented.CXCL2, a pivotal member of the CXC chemokine subfamily, orchestrates the recruitment of MDSCs and fosters angiogenesis via its engagement with the C-X-C motif chemokine receptor 2 (CXCR2) receptor (82, 83). Here, CXCL2 is linked to lung adenocarcinoma.