Key cytokines (IL-4, IL-5, and IL-13), type 2 chemokines (eosinophil cationic protein, eotaxin-1, eotaxin-2, eotaxin-3, pulmonary and activation-regulated chemokine, thymus and activation-regulated chemokine, and monocyte chemoattractant protein), and eosinophils show a significant increase in CRSwNP's type 2 inflammatory signature compared to healthy controls (16, 19, 20). The gene discussed is IL5; the disease is chronic rhinosinusitis with nasal polyps.