NF1 and plexiform neurofibroma: Based on the National Institutes of Health (NIH), the clinical criteria for the diagnosis of NF-1 are the following, of which at least two should be present: the presence of six or more café-au-lait spots, two or more neurofibromas of any kind, or a single plexiform neurofibroma, freckling in the axillary or inguinal region, optic glioma, two or more Lisch nodules (iris hamartomas), a distinctive osseous lesion such as sphenoid dysplasia or thinning of long bone cortex with or without pseudoarthrosis, and a first-degree relative with NF-1 [1,4,5].