Patient-derived tumor-like HSP90AA1 is a key protein in the cancer pathway, prostate cancer pathway and PI3K-Akt signaling pathway, and it also belongs to the HSP90 family, which interacts with various co-chaperones to regulate its substrate recognition, ATPase cycle and chaperone function (33, 34). The gene discussed is HSP90AB1; the disease is Familial prostate cancer.