NFKB1 and systemic lupus erythematosus: This is closely linked to the inhibition of the MAPK and NF-kB signaling pathways, with the inhibition of the IKK/NF-κB pathway downregulating caspase-3 expression to reduce liver cell apoptosis, providing a basis for these preparations to serve as alternative drugs for liver diseases in systemic lupus erythematosus (64).