A study by Cao P. et al. Found that quercetin prevents MAFLD via AMPK-mediated mitochondrial autophagy (Cao et al., 2023), and it has also been suggested that quercetin, by down-regulating the mTOR/YY1 signaling pathway converts cholesterol to bile acids, which leads to an increase in CYP7A1 activity, restores cholesterol homeostasis, and exerts hepatoprotective effects against T2DM-associated MAFLD (Yang et al., 2023). Here, YY1 is linked to type 2 diabetes mellitus.